The actress died at Cedars-Sinai Medical Centre near Beverly Hills, a hospital spokeswoman has confirmed.
According to the LA Times, Murphy went into cardiac arrest, but hospital sources have not revealed the cause of death.
It is said that LA fire department received a medical call from Murphy’s home in West Hollywood at 0800 local time.
And two hours later, she was pronounced dead at hospital.
Murphy grew up in New Jersey, started her career with Clueless and rose to stardom in 8 Mile alongside rapper Eminem, reports BBC News.
Murphy, who also starred in film like Just Married, was married to British screenwriter Simon Monjack.
She had once dated Ashton Kutcher, who co-starred with her in the 2003 romantic comedy, Just Married.
Kutcher tweeted Sunday morning about Murphy’s death: “2day the world lost a little piece of sunshine.”
“My deepest condolences go out 2 Brittany’s family, her husband & her amazing mother Sharon,” he added.
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